Yes, some imprints of Holiday House do accept manuscript submissions, such as Pixel+Ink.
Pixel+Ink is a publisher of fiction for children aged 3-13, including picture books, chapter books, middle grade and graphic novels. They periodically hold open submission processes where authors can directly submit their manuscripts without the need for a literary agent. To find more about their manuscript submission process, take a look at their website.
What other publishers are accepting manuscripts this month?
I understand it is hard to find publishers that accept manuscript submissions! To help authors like yourself, I’ve put together lists of publishers who are accepting manuscript submissions this month in a variety of genres, including romance, fantasy, mystery, thriller, horror, nonfiction and literary fiction. You can find my full list of publishers on my blog.
Otherwise, check out my pre-querying package or developmental editing services to make sure your manuscript is in top shape before approaching a publisher!